Support for ovarian health

• Aids in the management of polycystic ovarian syndrome (PCOS) by helping to restore normal ovarian function
• Aids in the management of PCOS’s hormonal and metabolic conditions by promoting healthy glucose metabolism
• Aids in the management of PCOS by reducing oxidative stresses
• Helps to restore ovulation and oocyte quality and to normalize menstrual cycle irregularities
• Helps to reduce serum testosterone in women with PCOS

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting up to 20% of women of reproductive age.¹ PCOS is associated with elevated male sex hormones, impaired insulin sensitivity and reproductive dysfunction, including menstrual irregularity and infertility.¹ Myo-inositol helps restore the activities of ovaries in PCOS patients through its role as a precursor to inositol 1,4,5-triphosphate (InsP3), which regulates menstrual cycle hormones and oocyte maturation.^3,4 Myo-inositol also promotes the production of inositolphosphoglycans (IPG), which activate enzymes involved in glucose metabolism.³ In a clinical trial involving 42 women with PCOS, participants were randomized to consume 400 mcg of folic acid alone or in combination with 4 g of myo-inositol daily for six to eight weeks.⁵ When compared to the placebo folic acid group, women in the myo-inositol group experienced more cycles of ovulation (69.5% ovulated in the myo-inositol group compared with 21% in the placebo group), lower testosterone levels, and improved insulin sensitivity.⁵

REFERENCES
1. Misso M, Boyle J, Norman R, Teede H. Semin Reprod Med. 2014 May;32(3):230–40.
2. Carlomagno G, Unfer V. Eur Rev Med Pharmacol Sci. 2011 Aug;15(8):931-6.
3. Unfer V, Carlomagno G, Dante G, Facchinetti F. Gynecol Endocrinol. 2012 Jul;28(7): 509–15.
4. Govindarajan C, Pitchaipillai R, Shanmugasundaram B, Thangam S, Arokiasamy J, Pillai MS. World J Pharm Pharm Sci. 2015;4(6):137-55.
5. Costantino D, Minozzi G, Minozzi, E, Guaraldi C. Eur Rev Med Pharmacol Sci. 2009 Mar-Apr;13(2):105-10.