Research tells us that a low level of 2-hydroxyestrone and a high level of 16 alpha-hydroxyestrone is not desired. DIM works by helping to increase 2-hydroxyestrone, and therefore improves the 2/16 hydroxyestrone ratio. DIM supplementation improves the estrogen ratio in a favourable direction that protects both men and women without the negative effect of raising 4 hydroxyestrogen.

DIM-Evail™ provides 100 mg of diindolylmethane (DIM), a compound classified as a “plant indole.” Plant indoles are also called glucosinolates, which are found in cruciferous vegetables such as broccoli, cabbage, and cauliflower, and they are among the nutrients responsible for the widely recognized healthful properties of these foods, including the support of a healthy estrogen balance. DIM-Evail™ is manufactured using Designs for Health’s proprietary Evail® emulsification technology, which is designed to enhance the bioavailability and absorption of bioactive ingredients. This Evail® process uses quillaja extract along with delta- and gamma-tocotrienols and medium-chain triglycerides to support absorption.

Diindolylmethane (DIM) is derived from the primary plant indole found in cruciferous vegetables, known as indole-3-carbinol (I3C). Mastication, cooking, and other actions activate the enzyme myrosinase to convert I3C to DIM. Stomach acid additionally contributes to the formation of DIM, which is a more stable compound than I3C. Research identifies beneficial actions of DIM on estrogen metabolism and associated conditions. Estrogen Metabolism Estrogen balance plays an important role in health, and disturbances of this hormone are associated with polycystic ovary syndrome, endometriosis, osteoporosis, Alzheimer’s disease, autoimmune disorders, male hypogonadism, schizophrenia, and breast, ovarian, and other estrogen-related cancers. Estrogen is involved in glucose homeostasis, lipid homeostasis, bone metabolism, brain function, follicular growth, skeletal growth, and ovulation. Estrogen biosynthesis involves the aromatization of androgen into estrogen.