Many epidemiological studies have been conducted demonstrating that high isoflavone intake has bone-sparing effects. Research suggests that genistein exerts its effect by managing the metabolic imbalance in bone tissue induced by ovarian hormone depletion, an important fact since the primary type of osteoporosis affects postmenopausal women. Genistein is a phytoestrogen that acts as a mild SERM (selective estrogen receptor modulator) which may positively regulate bone cell metabolism without serious side effects.