Quercetin could be used as an effective prophylactic treatment option for managing coronavirus COVID-19 infections.1 This ground-breaking application for quercetin is being proposed by a team of Canadian scientists at the Clinical Research Institute of Montreal (IRCM).1
Quercetin is a unique bioflavonoid that exhibits antiallergic, antiviral, and immune enhancing activities.2 Substantial research evidence supports the antiviral efficacy of quercetin.3, 4, 5
In one study, quercetin was found to protect patients from severe complications associated with the pandemic influenza A (H1N1) virus infection.3 It has been proposed that quercetin may exert its antiviral activity via interaction with viral HA protein, thereby inhibiting virus entry into the cell. Quercetin has been shown to reduce infection risk and augment innate immune function.2
Additionally, quercetin is an effective and safe therapeutic option for allergies, as it has been shown to inhibit mast-cell secretion and has the ability to downregulate histidine decarboxylase (HDC) mRNA from human mast cells.6 Quercetin inhibits the inflammatory process that is regulated by an increased release in neutrophils. The release of neutrophils leads to the destabilization of mast cells and their subsequent release of histamine and leukotrienes.7 By preventing the release of neutrophils, quercetin is therefore able to add stability to the mast-cell membrane, to help prevent degranulation and subsequent allergy symptoms.
Bromelain is a proteolytic enzyme that has been demonstrated to be an effective mucolytic and anti-inflammatory agent for respiratory disorders. Bromelain counteracts the fibrin and kinin pathways, which stimulate plasmin. Plasmin blocks endogenous arachidonic-acid mobilization and reduces prostaglandin synthesis, which reduces localized inflammation and edema. Bromelain may synergistically enhance the effectiveness of quercetin.
NFH Quercetin SAP provides high quality quercetin and bromelain in a vegetable capsule that can be used as an adjuvant therapeutic option for the management of infections and allergies.
Qiu, X., et al. Antimicrobial Agents and Chemotherapy. 2016; 60(9): 182-88.
Wu, W., et al. Viruses. 2016; 8(1): 6.
Uchide, N., et al. Molecules. 2011;16(3):2032-52.
Kempuraj, D., et al. Clinical and Experimental Medicine. 2006; 6(4): 150–56.
Thornhill, S.M. and A.M. Kelly. Alternative Medicine Review. 200; 5(5): 448–54.
What is Quercetin:
Quercetin is a bioflavonoid found in onions, apples, black tea, and grapefruit. Quercetin has antioxidant activity and is used in herbal medicine as a blood vessel protectant. Mast cells contribute to the inflammatory process in allergic reactions, where immunologic stimulation leads to degranulation of the mast cell, as well as to the generation of numerous cytokines and inflammatory mediators. Many studies have explored the effect of quercetin for managing allergies, as it has been shown to inhibit mast-cell secretions and has the ability to downregulate histamine production via inhibition of the enzyme histidine decarboxylase (HDC) mRNA from human mast cells.
Bromelain is a proteolytic digestive enzyme derived from the stem of the pineapple plant. Bromelain has been found to counteract the fibrin and kinin pathways, which stimulate plasmin that blocks endogenous arachidonic-acid mobilization and reduces prostaglandin synthesis, which reduces localized inflammation and edema. Studies suggest that bromelain may also enhance the effectiveness of quercetin.